Pharmacological inhibition of STING reduces neuroinflammation-mediated damage post-traumatic brain injury

AL Fryer; A Abdullah; F Mobilio; A Jobling; Z Moore; M de Veer; G Zheng; BX Wong; JM Taylor; PJ Crack

Journal article

Pharmacological inhibition of STING reduces neuroinflammation-mediated damage post-traumatic brain injury

AL Fryer, A Abdullah, F Mobilio, A Jobling, Z Moore, M de Veer, G Zheng, BX Wong, JM Taylor, PJ Crack

British Journal of Pharmacology | WILEY | Published : 2024

DOI: 10.1111/bph.16347

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Abstract

Background and Purpose: Traumatic brain injury (TBI) remains a major public health concern worldwide with unmet effective treatment. Stimulator of interferon genes (STING) and its downstream type-I interferon (IFN) signalling are now appreciated to be involved in TBI pathogenesis. Compelling evidence have shown that STING and type-I IFNs are key in mediating the detrimental neuroinflammatory response after TBI. Therefore, pharmacological inhibition of STING presents a viable therapeutic opportunity in combating the detrimental neuroinflammatory response after TBI. Experimental Approach: This study investigated the neuroprotective effects of the small-molecule STING inhibitor n-(4-iodophenyl)..

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University of Melbourne Researchers

Andrew Jobling Author

Zachery Moore Author

Bruce Wong Author

Peter Crack Author

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Grants

Awarded by Brain Foundation

Funding Acknowledgements

This work was supported by grants from the National Health and Medical Research Council of Australia (NHMRC; Project Grant 1156744) to P.J.C and the Brain Foundation to A.A. We would like to thank the staff of the Melbourne Bioresources Platform for their expertise. Open access publishing facilitated by The University of Melbourne, as part of the Wiley - The University of Melbourne agreement via the Council of Australian University Librarians.